Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1–42‐mediated cytotoxicity

Phosphodiesterase (PDE) inhibitors are currently under evaluation as agents that may facilitate the improvement of cognitive impairment associated with Alzheimer's disease. Our aim was to determine whether inhibitors of PDEs 4, 5 and 9 could alleviate the cytotoxic effects of amyloid beta 1–42...

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Detalles Bibliográficos
Autores principales: Cameron, Ryan T., Whiteley, Ellanor, Day, Jon P., Parachikova, Anna I., Baillie, George S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221464/
https://www.ncbi.nlm.nih.gov/pubmed/28097089
http://dx.doi.org/10.1002/2211-5463.12156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221464/
https://www.ncbi.nlm.nih.gov/pubmed/28097089
http://dx.doi.org/10.1002/2211-5463.12156

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