Reconstituting regulation of the canonical Wnt pathway by engineering a minimal β-catenin destruction machine

Negatively regulating key signaling pathways is critical to development and altered in cancer. Wnt signaling is kept off by the destruction complex, which is assembled around the tumor suppressors APC and Axin and targets β-catenin for destruction. Axin and APC are large proteins with many domains a...

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Detalles Bibliográficos
Autores principales: Pronobis, Mira I., Deuitch, Natalie, Posham, Vinya, Mimori-Kiyosue, Yuko, Peifer, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221518/
https://www.ncbi.nlm.nih.gov/pubmed/27852897
http://dx.doi.org/10.1091/mbc.E16-07-0557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221518/
https://www.ncbi.nlm.nih.gov/pubmed/27852897
http://dx.doi.org/10.1091/mbc.E16-07-0557

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