Leukotriene B₄ Metabolism and p70S6 Kinase 1 Inhibitors: PF-4708671 but Not LY2584702 Inhibits CYP4F3A and the ω-Oxidation of Leukotriene B₄ In Vitro and In Cellulo

LTB(4) is an inflammatory lipid mediator mainly biosynthesized by leukocytes. Since its implication in inflammatory diseases is well recognized, many tools to regulate its biosynthesis have been developed and showed promising results in vitro and in vivo, but mixed results in clinical trials. Recent...

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Detalles Bibliográficos
Autores principales: Archambault, Anne-Sophie, Turcotte, Caroline, Martin, Cyril, Lefebvre, Julie S., Provost, Véronique, Laviolette, Michel, Flamand, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222342/
https://www.ncbi.nlm.nih.gov/pubmed/28068410
http://dx.doi.org/10.1371/journal.pone.0169804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222342/
https://www.ncbi.nlm.nih.gov/pubmed/28068410
http://dx.doi.org/10.1371/journal.pone.0169804

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