Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer

Structural rearrangements of HIV-1 glycoprotein Env promote viral entry through membrane fusion. Env is a symmetric homotrimer with each protomer composed of surface subunit gp120 and transmembrane subunit gp41. Cellular CD4- and chemokine receptor-binding to gp120 coordinate conformational changes...

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Detalles Bibliográficos
Autores principales: Khasnis, Mukta D., Halkidis, Konstantine, Bhardwaj, Anshul, Root, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222517/
https://www.ncbi.nlm.nih.gov/pubmed/27992602
http://dx.doi.org/10.1371/journal.ppat.1006098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222517/
https://www.ncbi.nlm.nih.gov/pubmed/27992602
http://dx.doi.org/10.1371/journal.ppat.1006098

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