Cargando…

Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer

Structural rearrangements of HIV-1 glycoprotein Env promote viral entry through membrane fusion. Env is a symmetric homotrimer with each protomer composed of surface subunit gp120 and transmembrane subunit gp41. Cellular CD4- and chemokine receptor-binding to gp120 coordinate conformational changes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khasnis, Mukta D., Halkidis, Konstantine, Bhardwaj, Anshul, Root, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222517/ https://www.ncbi.nlm.nih.gov/pubmed/27992602 http://dx.doi.org/10.1371/journal.ppat.1006098

Ejemplares similares

Regulation of epitope exposure in the gp41 membrane-proximal external region through interactions at the apex of HIV-1 Env
por: Schapiro, Hannah M., et al.
Publicado: (2022)

HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes
por: Li, Wenwei, et al.
Publicado: (2023)

Asymmetric Deactivation of HIV-1 gp41 following Fusion Inhibitor Binding
por: Kahle, Kristen M., et al.
Publicado: (2009)

Antiviral properties of two trimeric recombinant gp41 proteins
por: Delcroix-Genête, Delphine, et al.
Publicado: (2006)

Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike
por: Lee, Jeong Hyun, et al.
Publicado: (2015)

Antibody to gp41 MPER Alters Functional Properties of HIV-1 Env without Complete Neutralization
por: Kim, Arthur S., et al.
Publicado: (2014)

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations
por: Ma, Xiaochu, et al.
Publicado: (2018)

Structure and immune recognition of trimeric prefusion HIV-1 Env
por: Pancera, Marie, et al.
Publicado: (2014)

Antigenic and immunosuppressive properties of a trimeric recombinant transmembrane envelope protein gp41 of HIV-1
por: Mühle, Michael, et al.
Publicado: (2017)

Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles
por: Kumar, Sonu, et al.
Publicado: (2021)

Functional Characterization of Two scFv-Fc Antibodies from an HIV Controller Selected on Soluble HIV-1 Env Complexes: A Neutralizing V3- and a Trimer-Specific gp41 Antibody
por: Trott, Maria, et al.
Publicado: (2014)

Correction: Functional Characterization of Two scFv-Fc Antibodies from an HIV Controller Selected on Soluble HIV-1 Env Complexes: A Neutralizing V3- and a Trimer-Specific gp41 Antibody
Publicado: (2014)

Trimeric HIV Env provides epitope occlusion mediated by hypervariable loops
por: Moscoso, Carlos G., et al.
Publicado: (2014)

Heterologous Combination of VSV-GP and NYVAC Vectors Expressing HIV-1 Trimeric gp145 Env as Vaccination Strategy to Induce Balanced B and T Cell Immune Responses
por: Perdiguero, Beatriz, et al.
Publicado: (2019)

Viral vector delivery of Env trimer immunogens
por: Parks, CL, et al.
Publicado: (2012)

P19-23. Putative prefusion mechanism of HIV-1 Env revealed by ligand-induced quaternary alterations in o-gp140 trimers
por: Moscoso, CG, et al.
Publicado: (2009)

Trimeric gp120-specific bovine monoclonal antibodies require cysteine and aromatic residues in CDRH3 for high affinity binding to HIV Env
por: Heydarchi, Behnaz, et al.
Publicado: (2016)

Native‐like Env trimers as a platform for HIV‐1 vaccine design
por: Sanders, Rogier W., et al.
Publicado: (2017)

Antibody Recognition of CD4-Induced Open HIV-1 Env Trimers
por: Yang, Zhi, et al.
Publicado: (2022)

Virus-like particles highly expressing DC-SIGN concentrate trimeric HIV-envelope proteins with noncovalently linked immunoreactive gp120 and gp41
por: Vyas, GN
Publicado: (2012)

Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41
por: Gustchina, Elena, et al.
Publicado: (2010)

Insights into the Conformation of the Membrane Proximal Regions Critical to the Trimerization of the HIV-1 gp41 Ectodomain Bound to Dodecyl Phosphocholine Micelles
por: Louis, John M., et al.
Publicado: (2016)

Crystal structures of trimeric HIV Env with entry inhibitors BMS-378806 and BMS-626529
por: Pancera, Marie, et al.
Publicado: (2017)

Immunogenicity of stabilized HIV-1 Env trimers delivered by self-amplifying mRNA
por: Aldon, Yoann, et al.
Publicado: (2021)

Structure dynamics of HIV-1 Env trimers on native virions engaged with living T cells
por: Carlon-Andres, Irene, et al.
Publicado: (2021)

gp41: HIV's shy protein
por: Zwick, Michael B, et al.
Publicado: (2004)

Complexes of Neutralizing and Non-Neutralizing Affinity Matured Fabs with a Mimetic of the Internal Trimeric Coiled-Coil of HIV-1 gp41
por: Gustchina, Elena, et al.
Publicado: (2013)

Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits
por: Yasmeen, Anila, et al.
Publicado: (2014)

Design of lipid nanoparticle delivery agents for multivalent display of recombinant Env trimers in HIV vaccination
por: Pejawar-Gaddy, S, et al.
Publicado: (2012)

Design of Lipid Nanocapsule Delivery Vehicles for Multivalent Display of Recombinant Env Trimers in HIV Vaccination
por: Pejawar-Gaddy, Sharmila, et al.
Publicado: (2014)

Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice
por: Soldemo, Martina, et al.
Publicado: (2017)

Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer
por: Sarkar, Anita, et al.
Publicado: (2018)

Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques
por: Zhao, Fangzhu, et al.
Publicado: (2020)

Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs
por: Niu, Jun, et al.
Publicado: (2023)

Enhancing Exposure of HIV-1 Neutralization Epitopes through Mutations in gp41
por: Blish, Catherine A, et al.
Publicado: (2008)

Effects of the I559P gp41 Change on the Conformation and Function of the Human Immunodeficiency Virus (HIV-1) Membrane Envelope Glycoprotein Trimer
por: Alsahafi, Nirmin, et al.
Publicado: (2015)

Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection
por: Wang, Chao, et al.
Publicado: (2016)

Neutralizing antibodies elicited in rabbits by patient-derived Env trimer immunization
por: Heyndrickx, L, et al.
Publicado: (2012)

Selected HIV-1 Env Trimeric Formulations Act as Potent Immunogens in a Rabbit Vaccination Model
por: Heyndrickx, Leo, et al.
Publicado: (2013)

Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen
por: Struwe, Weston B., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_qt7qrfsa18oqi031uha81tfr6n