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Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist
The causative agent of toxoplasmosis, the intracellular parasite Toxoplasma gondii, delivers a protein, GRA24, into the cells it infects that interacts with the mitogen-activated protein (MAP) kinase p38α (MAPK14), leading to activation and nuclear translocation of the host kinase and a subsequent i...
Autores principales: | Pellegrini, Erika, Palencia, Andrés, Braun, Laurence, Kapp, Ulrike, Bougdour, Alexandre, Belrhali, Hassan, Bowler, Matthew W., Hakimi, Mohamed-Ali |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222587/ https://www.ncbi.nlm.nih.gov/pubmed/27889209 http://dx.doi.org/10.1016/j.str.2016.10.011 |
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