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Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection

The sarcomeric cytoskeleton is a network of modular proteins that integrate mechanical and signaling roles. Obscurin, or its homolog obscurin-like-1, bridges the giant ruler titin and the myosin crosslinker myomesin at the M-band. Yet, the molecular mechanisms underlying the physical obscurin(-like-...

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Detalles Bibliográficos
Autores principales: Pernigo, Stefano, Fukuzawa, Atsushi, Beedle, Amy E.M., Holt, Mark, Round, Adam, Pandini, Alessandro, Garcia-Manyes, Sergi, Gautel, Mathias, Steiner, Roberto A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222588/
https://www.ncbi.nlm.nih.gov/pubmed/27989621
http://dx.doi.org/10.1016/j.str.2016.11.015