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Normalisation against Circadian and Age-Related Disturbances Enables Robust Detection of Gene Expression Changes in Liver of Aged Mice
The expression of some genes is affected by age. To detect such age-related changes, their expression levels are related to constant marker genes. However, transcriptional noise increasing with advancing age renders difficult the identification of real age-related changes because it may affect the m...
Autores principales: | Fonseca Costa, Sara S., Wegmann, Daniel, Ripperger, Jürgen A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222604/ https://www.ncbi.nlm.nih.gov/pubmed/28068403 http://dx.doi.org/10.1371/journal.pone.0169615 |
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