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Molecular Mimics of Classic P-Glycoprotein Inhibitors as Multidrug Resistance Suppressors and Their Synergistic Effect on Paclitaxel

P-glycoprotein (Pgp) is a membrane bound efflux pump spread in a variety of tumor cells and considered as a main component of multidrug resistance (MDR) to chemotherapies. In this work, three groups of compounds (imidazolone, oxazolone and vinyl dipeptide derivatives) were synthesized aiming to deve...

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Detalles Bibliográficos
Autores principales: El-Araby, Moustafa E., Omar, Abdelsattar M., Khayat, Maan T., Assiri, Hanan A., Al-Abd, Ahmed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222621/
https://www.ncbi.nlm.nih.gov/pubmed/28068430
http://dx.doi.org/10.1371/journal.pone.0168938