DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA Methyltransferases

Stable expression of Foxp3 is ensured by demethylation of CpG motifs in the Foxp3 intronic element, the conserved non-coding sequence 2 (CNS2), which persists throughout the lifespan of regulatory T cells (Tregs). However, little is known about the mechanisms on how CNS2 demethylation is sustained....

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Detalles Bibliográficos
Autores principales: Nair, Varun Sasidharan, Song, Mi Hye, Ko, Myunggon, Oh, Kwon Ik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223106/
https://www.ncbi.nlm.nih.gov/pubmed/27989104
http://dx.doi.org/10.14348/molcells.2016.0276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223106/
https://www.ncbi.nlm.nih.gov/pubmed/27989104
http://dx.doi.org/10.14348/molcells.2016.0276

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