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Covalent modification of pericardial patches for sustained rapamycin delivery inhibits venous neointimal hyperplasia
Prosthetic grafts and patches are commonly used in cardiovascular surgery, however neointimal hyperplasia remains a significant concern, especially under low flow conditions. We hypothesized that delivery of rapamycin from nanoparticles (NP) covalently attached to patches allows sustained site-speci...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223139/ https://www.ncbi.nlm.nih.gov/pubmed/28071663 http://dx.doi.org/10.1038/srep40142 |