Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression

The angiogenic switch, the time at which a tumor becomes vascularized, is a critical step in tumor progression. Indeed, without blood supply, tumors will fail to grow beyond 1 mm(3) and are unlikely to disseminate. The extracellular matrix (ECM), a major component of the tumor microenvironment, is k...

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Detalles Bibliográficos
Autores principales: Naba, Alexandra, Clauser, Karl R., Mani, D. R., Carr, Steven A., Hynes, Richard O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223159/
https://www.ncbi.nlm.nih.gov/pubmed/28071719
http://dx.doi.org/10.1038/srep40495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223159/
https://www.ncbi.nlm.nih.gov/pubmed/28071719
http://dx.doi.org/10.1038/srep40495

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