Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer through activation of p53-LKB1 and p73-LKB1 axes

Functional reactivation of p53 pathway, although arduous, can potentially provide a broad-based strategy for cancer therapy owing to frequent p53 inactivation in human cancer. Using a phosphoprotein-screening array, we found that Benzyl Isothiocynate, (BITC) increases p53 phosphorylation in breast c...

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Detalles Bibliográficos
Autores principales: Xie, Bei, Nagalingam, Arumugam, Kuppusamy, Panjamurthy, Muniraj, Nethaji, Langford, Peter, Győrffy, Balázs, Saxena, Neeraj K., Sharma, Dipali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223184/
https://www.ncbi.nlm.nih.gov/pubmed/28071670
http://dx.doi.org/10.1038/srep40070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223184/
https://www.ncbi.nlm.nih.gov/pubmed/28071670
http://dx.doi.org/10.1038/srep40070

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