Novel long-chain compounds with both immunomodulatory and MenA inhibitory activities against Staphylococcus aureus and its biofilm

Menaquinone (MK) biosynthesis pathway is a potential target for evaluating antimicrobials in gram-positive bacteria. Here, 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA) was targeted to reduce methicillin-resistant Staphylococcus aureus (MRSA) growth. MenA inhibiting, long chain-based compounds...

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Detalles Bibliográficos
Autores principales: Choi, Seoung-ryoung, Frandsen, Joel, Narayanasamy, Prabagaran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223195/
https://www.ncbi.nlm.nih.gov/pubmed/28071679
http://dx.doi.org/10.1038/srep40077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223195/
https://www.ncbi.nlm.nih.gov/pubmed/28071679
http://dx.doi.org/10.1038/srep40077

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