MT5-MMP Promotes Alzheimer’s Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro

We previously reported that deficiency of membrane-type five matrix metalloproteinase (MT5-MMP) prevents amyloid pathology in the cortex and hippocampus of 5xFAD mice, and ameliorates the functional outcome. We have now investigated whether the integrity of another important area affected in Alzheim...

Descripción completa

Detalles Bibliográficos
Autores principales: Baranger, Kévin, Bonnet, Amandine E., Girard, Stéphane D., Paumier, Jean-Michel, García-González, Laura, Elmanaa, Wejdane, Bernard, Anne, Charrat, Eliane, Stephan, Delphine, Bauer, Charlotte, Moschke, Katrin, Lichtenthaler, Stefan F., Roman, François S., Checler, Frédéric, Khrestchatisky, Michel, Rivera, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223243/
https://www.ncbi.nlm.nih.gov/pubmed/28119565
http://dx.doi.org/10.3389/fnmol.2016.00163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223243/
https://www.ncbi.nlm.nih.gov/pubmed/28119565
http://dx.doi.org/10.3389/fnmol.2016.00163

Ejemplares similares