Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer

BACKGROUND: BRCA1/2-deficient ovarian carcinomas are recognized as target for Poly (ADP-ribose) polymerase (PARP) inhibitors. BRCA1 and BRCA2 proteins are involved in homologous recombination repair of double-strand DNA breaks. The relevance of other homologous recombination repair proteins, e.g. MR...

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Detalles Bibliográficos
Autores principales: Brandt, Simone, Samartzis, Eleftherios P., Zimmermann, Anne-Katrin, Fink, Daniel, Moch, Holger, Noske, Aurelia, Dedes, Konstantin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223425/
https://www.ncbi.nlm.nih.gov/pubmed/28073364
http://dx.doi.org/10.1186/s12885-016-3026-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223425/
https://www.ncbi.nlm.nih.gov/pubmed/28073364
http://dx.doi.org/10.1186/s12885-016-3026-2

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