Cargando…

Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer

BACKGROUND: BRCA1/2-deficient ovarian carcinomas are recognized as target for Poly (ADP-ribose) polymerase (PARP) inhibitors. BRCA1 and BRCA2 proteins are involved in homologous recombination repair of double-strand DNA breaks. The relevance of other homologous recombination repair proteins, e.g. MR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brandt, Simone, Samartzis, Eleftherios P., Zimmermann, Anne-Katrin, Fink, Daniel, Moch, Holger, Noske, Aurelia, Dedes, Konstantin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223425/ https://www.ncbi.nlm.nih.gov/pubmed/28073364 http://dx.doi.org/10.1186/s12885-016-3026-2

Ejemplares similares

MRN (MRE11-RAD50-NBS1) Complex in Human Cancer and Prognostic Implications in Colorectal Cancer
por: Situ, Yiling, et al.
Publicado: (2019)

Mutation Spectra of the MRN (MRE11, RAD50, NBS1/NBN) Break Sensor in Cancer Cells
por: McPherson, Matthew T., et al.
Publicado: (2020)

Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis
por: Ho, Vincent, et al.
Publicado: (2018)

Effect of MRE11 Loss on PARP-Inhibitor Sensitivity in Endometrial Cancer In Vitro
por: Koppensteiner, Romana, et al.
Publicado: (2014)

Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex
por: Lee, Ji-Hoon, et al.
Publicado: (2013)

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks
por: Lee, Joon, et al.
Publicado: (2013)

The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers
por: Ziółkowska-Suchanek, Iwona, et al.
Publicado: (2013)

Importance of Germline and Somatic Alterations in Human MRE11, RAD50, and NBN Genes Coding for MRN Complex
por: Otahalova, Barbora, et al.
Publicado: (2023)

MRE11 and RAD50, but not NBS1, are essential for gene targeting in the moss Physcomitrella patens
por: Kamisugi, Yasuko, et al.
Publicado: (2012)

A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex
por: Rahman, Samiur, et al.
Publicado: (2020)

Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers
por: Alblihy, Adel, et al.
Publicado: (2021)

Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma
por: Schuetz, Johanna M, et al.
Publicado: (2009)

The role of the Mre11–Rad50–Nbs1 complex in double-strand break repair—facts and myths
por: Takeda, Shunichi, et al.
Publicado: (2016)

MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment
por: Bian, Lei, et al.
Publicado: (2019)

Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency
por: Mariggiò, Giuseppe, et al.
Publicado: (2017)

Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
por: Jazayeri, Ali, et al.
Publicado: (2008)

Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin
por: Spycher, Christoph, et al.
Publicado: (2008)

The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis
por: Taylor, Elaine M., et al.
Publicado: (2010)

Mre11-Rad50–dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1
por: Limbo, Oliver, et al.
Publicado: (2018)

MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts
por: Chang, Emily Yun-Chia, et al.
Publicado: (2019)

ARID1A Mutations and PI3K/AKT Pathway Alterations in Endometriosis and Endometriosis-Associated Ovarian Carcinomas
por: Samartzis, Eleftherios P., et al.
Publicado: (2013)

Deubiquitinase USP2 stabilizes the MRE11–RAD50–NBS1 complex at DNA double-strand break sites by counteracting the ubiquitination of NBS1
por: Kim, Hyunsup, et al.
Publicado: (2022)

Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest
por: Franchitto, Annapaola, et al.
Publicado: (2002)

MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex
por: Lee, Kyung Yong, et al.
Publicado: (2015)

Cisplatin-induced cell death increases the degradation of the MRE11-RAD50-NBS1 complex through the autophagy/lysosomal pathway
por: Belmonte-Fernández, Alejandro, et al.
Publicado: (2022)

Expression of the G protein-coupled estrogen receptor (GPER) in endometriosis: a tissue microarray study
por: Samartzis, Nicolas, et al.
Publicado: (2012)

Stable maintenance of the Mre11-Rad50-Nbs1 complex is sufficient to restore the DNA double-strand break response in cells lacking RecQL4 helicase activity
por: Kim, Hyunsup, et al.
Publicado: (2021)

Variations in Mre11/Rad50/Nbs1 status and DNA damage-induced S-phase arrest in the cell lines of the NCI60 panel
por: Garner, Kristen M, et al.
Publicado: (2011)

Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling
por: Henrich, Sarah Marie, et al.
Publicado: (2017)

NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle–dependent degradation of protein
por: Zhou, Hui, et al.
Publicado: (2017)

MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends
por: Sharma, Sheetal, et al.
Publicado: (2021)

Tracking the origin of simultaneous endometrial and ovarian cancer by next-generation sequencing – a case report
por: Valtcheva, Nadejda, et al.
Publicado: (2017)

The Rad50 Coiled Coil Domain is indispensable for Mre11 complex functions
por: Hohl, Marcel, et al.
Publicado: (2011)

Dynamic Properties of the DNA Damage Response Mre11/Rad50 Complex
por: Vertemara, Jacopo, et al.
Publicado: (2023)

Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11–Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links
por: Pasadi, Sanjeev, et al.
Publicado: (2020)

Germline variants in MRE11/RAD50/NBN complex genes in childhood leukemia
por: Mosor, Maria, et al.
Publicado: (2013)

Mre11-Rad50 oligomerization promotes DNA double-strand break repair
por: Kissling, Vera M., et al.
Publicado: (2022)

S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex
por: Chen, Yu-Jie, et al.
Publicado: (2016)

The G Protein-Coupled Estrogen Receptor (GPER) Is Expressed in Two Different Subcellular Localizations Reflecting Distinct Tumor Properties in Breast Cancer
por: Samartzis, Eleftherios P., et al.
Publicado: (2014)

Activation of the DNA-repair mechanism through NBS1 and MRE11 diffusion
por: Friis, Ida, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_uatisprhic1erqp4tpfhjgf473