Mechanistic Insights into the Binding of Class IIa HDAC Inhibitors toward Spinocerebellar Ataxia Type-2: A 3D-QSAR and Pharmacophore Modeling Approach

Spinocerebellar ataxia (SCA-2) type-2 is a rare neurological disorder among the nine polyglutamine disorders, mainly caused by polyQ (CAG) trinucleotide repeats expansion within gene coding ataxin-2 protein. The expanded trinucleotide repeats within the ataxin-2 protein sequesters transcriptional co...

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Detalles Bibliográficos
Autores principales: Sinha, Siddharth, Goyal, Sukriti, Somvanshi, Pallavi, Grover, Abhinav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223442/
https://www.ncbi.nlm.nih.gov/pubmed/28119557
http://dx.doi.org/10.3389/fnins.2016.00606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223442/
https://www.ncbi.nlm.nih.gov/pubmed/28119557
http://dx.doi.org/10.3389/fnins.2016.00606

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