Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers

Aptamers directed against human thrombin can selectively bind to two different exosites on the protein surface. The simultaneous use of two DNA aptamers, HD1 and HD22, directed to exosite I and exosite II respectively, is a very powerful approach to exploit their combined affinity. Indeed, strategie...

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Detalles Bibliográficos
Autores principales: Pica, Andrea, Russo Krauss, Irene, Parente, Valeria, Tateishi-Karimata, Hisae, Nagatoishi, Satoru, Tsumoto, Kouhei, Sugimoto, Naoki, Sica, Filomena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224481/
https://www.ncbi.nlm.nih.gov/pubmed/27899589
http://dx.doi.org/10.1093/nar/gkw1113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224481/
https://www.ncbi.nlm.nih.gov/pubmed/27899589
http://dx.doi.org/10.1093/nar/gkw1113

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