Asymmetric positioning of Cas1–2 complex and Integration Host Factor induced DNA bending guide the unidirectional homing of protospacer in CRISPR-Cas type I-E system

CRISPR–Cas system epitomizes prokaryote-specific quintessential adaptive defense machinery that limits the genome invasion of mobile genetic elements. It confers adaptive immunity to bacteria by capturing a protospacer fragment from invading foreign DNA, which is later inserted into the leader proxi...

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Detalles Bibliográficos
Autores principales: Yoganand, K.N.R., Sivathanu, R., Nimkar, Siddharth, Anand, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224486/
https://www.ncbi.nlm.nih.gov/pubmed/27899566
http://dx.doi.org/10.1093/nar/gkw1151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224486/
https://www.ncbi.nlm.nih.gov/pubmed/27899566
http://dx.doi.org/10.1093/nar/gkw1151

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