RHAU helicase stabilizes G4 in its nucleotide-free state and destabilizes G4 upon ATP hydrolysis

The DEAH-box ATP-dependent RHAU helicases specifically unfold RNA and DNA G-quadruplexes (G4s). However, it remains unclear how the RHAU's G4 unfolding activity is coupled to different stages of the ATPase cycle. Here, using a single-molecule manipulation approach, we show that binding of Droso...

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Detalles Bibliográficos
Autores principales: You, Huijuan, Lattmann, Simon, Rhodes, Daniela, Yan, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224510/
https://www.ncbi.nlm.nih.gov/pubmed/28069994
http://dx.doi.org/10.1093/nar/gkw881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224510/
https://www.ncbi.nlm.nih.gov/pubmed/28069994
http://dx.doi.org/10.1093/nar/gkw881

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