Cargando…
Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domains
Replication across damaged DNA templates is accompanied by transient formation of sister chromatid junctions (SCJs). Cells lacking Esc2, an adaptor protein containing no known enzymatic domains, are defective in the metabolism of these SCJs. However, how Esc2 is involved in the metabolism of SCJs re...
Autores principales: | Sebesta, Marek, Urulangodi, Madhusoodanan, Stefanovie, Barbora, Szakal, Barnabas, Pacesa, Martin, Lisby, Michael, Branzei, Dana, Krejci, Lumir |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224511/ https://www.ncbi.nlm.nih.gov/pubmed/27694623 http://dx.doi.org/10.1093/nar/gkw882 |
Ejemplares similares
-
Srs2 promotes Mus81–Mms4-mediated resolution of recombination intermediates
por: Chavdarova, Melita, et al.
Publicado: (2015) -
Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication
por: Urulangodi, Madhusoodanan, et al.
Publicado: (2015) -
Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity
por: Waizenegger, Anja, et al.
Publicado: (2020) -
A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes
por: Fadden, Andrew J., et al.
Publicado: (2013) -
A structure–function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance
por: Shemesh, Keren, et al.
Publicado: (2017)