Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia

Data integration stands to improve interpretation of RNAi screens which, as a result of off-target effects, typically yield numerous gene hits of which only a few validate. These off-target effects can result from seed matches to unintended gene targets (reagent-based) or cellular pathways, which ca...

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Detalles Bibliográficos
Autores principales: Wilson, Jennifer L., Dalin, Simona, Gosline, Sara, Hemann, Michael, Fraenkel, Ernest, Lauffenburger, Douglas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224708/
https://www.ncbi.nlm.nih.gov/pubmed/27315426
http://dx.doi.org/10.1039/c6ib00040a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224708/
https://www.ncbi.nlm.nih.gov/pubmed/27315426
http://dx.doi.org/10.1039/c6ib00040a

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