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Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia
Data integration stands to improve interpretation of RNAi screens which, as a result of off-target effects, typically yield numerous gene hits of which only a few validate. These off-target effects can result from seed matches to unintended gene targets (reagent-based) or cellular pathways, which ca...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224708/ https://www.ncbi.nlm.nih.gov/pubmed/27315426 http://dx.doi.org/10.1039/c6ib00040a |