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A Hypothesis Testing Based Method for Normalization and Differential Expression Analysis of RNA-Seq Data
Next-generation sequencing technologies have made RNA sequencing (RNA-seq) a popular choice for measuring gene expression level. To reduce the noise of gene expression measures and compare them between several conditions or samples, normalization is an essential step to adjust for varying sample seq...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224994/ https://www.ncbi.nlm.nih.gov/pubmed/28072846 http://dx.doi.org/10.1371/journal.pone.0169594 |