Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction

Optimization of a protein’s pharmaceutical properties is usually carried out by rational design and/or directed evolution. Here we test an alternative approach based on ancestral sequence reconstruction. Using available genomic sequence data on coagulation factor VIII and predictive models of molecu...

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Detalles Bibliográficos
Autores principales: Zakas, Philip M., Brown, Harrison C., Knight, Kristopher, Meeks, Shannon L., Spencer, H. Trent, Gaucher, Eric A., Doering, Christopher B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225049/
https://www.ncbi.nlm.nih.gov/pubmed/27669166
http://dx.doi.org/10.1038/nbt.3677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225049/
https://www.ncbi.nlm.nih.gov/pubmed/27669166
http://dx.doi.org/10.1038/nbt.3677

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