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Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction
Optimization of a protein’s pharmaceutical properties is usually carried out by rational design and/or directed evolution. Here we test an alternative approach based on ancestral sequence reconstruction. Using available genomic sequence data on coagulation factor VIII and predictive models of molecu...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225049/ https://www.ncbi.nlm.nih.gov/pubmed/27669166 http://dx.doi.org/10.1038/nbt.3677 |