Etirinotecan pegol administration is associated with lower incidences of neutropenia compared to irinotecan administration

PURPOSE: The relationship between incidences of neutropenia and 10-hydroxy-7-ethyl camptothecin (SN38) exposure was explored using SN38 pharmacokinetic and neutrophil count data from toxicology studies of etirinotecan pegol (EP) and irinotecan in beagle dogs. METHODS: Dogs received four weekly intra...

Descripción completa

Detalles Bibliográficos
Autores principales: Sy, S. Kenneth, Sweeney, Theresa D., Ji, Chunmei, Hoch, Ute, Eldon, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225190/
https://www.ncbi.nlm.nih.gov/pubmed/27904955
http://dx.doi.org/10.1007/s00280-016-3192-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225190/
https://www.ncbi.nlm.nih.gov/pubmed/27904955
http://dx.doi.org/10.1007/s00280-016-3192-6

Ejemplares similares