Synthesis of γ-pyrones via decarboxylative condensation of β-ketoacids

ABSTRACT: This manuscript describes the convergent synthesis of aryl- and alkyl-disubstituted γ-pyrones from β-ketoacids. The reaction proceeds in the presence of trifluoromethanesulfonic anhydride via an unprecedented decarboxylative auto-condensation of the starting material. Herein, the scope and...

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Autores principales: Merad, Jérémy, Maier, Thomas, Rodrigues, Catarina A. B., Maulide, Nuno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225206/
https://www.ncbi.nlm.nih.gov/pubmed/28127091
http://dx.doi.org/10.1007/s00706-016-1851-2
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author Merad, Jérémy
Maier, Thomas
Rodrigues, Catarina A. B.
Maulide, Nuno
author_facet Merad, Jérémy
Maier, Thomas
Rodrigues, Catarina A. B.
Maulide, Nuno
author_sort Merad, Jérémy
collection PubMed
description ABSTRACT: This manuscript describes the convergent synthesis of aryl- and alkyl-disubstituted γ-pyrones from β-ketoacids. The reaction proceeds in the presence of trifluoromethanesulfonic anhydride via an unprecedented decarboxylative auto-condensation of the starting material. Herein, the scope and limitations of this transformation are reported. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-52252062017-01-24 Synthesis of γ-pyrones via decarboxylative condensation of β-ketoacids Merad, Jérémy Maier, Thomas Rodrigues, Catarina A. B. Maulide, Nuno Monatsh Chem Original Paper ABSTRACT: This manuscript describes the convergent synthesis of aryl- and alkyl-disubstituted γ-pyrones from β-ketoacids. The reaction proceeds in the presence of trifluoromethanesulfonic anhydride via an unprecedented decarboxylative auto-condensation of the starting material. Herein, the scope and limitations of this transformation are reported. GRAPHICAL ABSTRACT: [Image: see text] Springer Vienna 2016-10-27 2017 /pmc/articles/PMC5225206/ /pubmed/28127091 http://dx.doi.org/10.1007/s00706-016-1851-2 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Paper
Merad, Jérémy
Maier, Thomas
Rodrigues, Catarina A. B.
Maulide, Nuno
Synthesis of γ-pyrones via decarboxylative condensation of β-ketoacids
title Synthesis of γ-pyrones via decarboxylative condensation of β-ketoacids
title_full Synthesis of γ-pyrones via decarboxylative condensation of β-ketoacids
title_fullStr Synthesis of γ-pyrones via decarboxylative condensation of β-ketoacids
title_full_unstemmed Synthesis of γ-pyrones via decarboxylative condensation of β-ketoacids
title_short Synthesis of γ-pyrones via decarboxylative condensation of β-ketoacids
title_sort synthesis of γ-pyrones via decarboxylative condensation of β-ketoacids
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225206/
https://www.ncbi.nlm.nih.gov/pubmed/28127091
http://dx.doi.org/10.1007/s00706-016-1851-2
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AT rodriguescatarinaab synthesisofgpyronesviadecarboxylativecondensationofbketoacids
AT maulidenuno synthesisofgpyronesviadecarboxylativecondensationofbketoacids

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