BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer

Chromosomal instability (CIN) contributes to cancer evolution, intratumor heterogeneity, and drug resistance. CIN is driven by chromosome segregation errors and a tolerance phenotype that permits the propagation of aneuploid genomes. Through genomic analysis of colorectal cancers and cell lines, we...

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Detalles Bibliográficos
Autores principales: López-García, Carlos, Sansregret, Laurent, Domingo, Enric, McGranahan, Nicholas, Hobor, Sebastijan, Birkbak, Nicolai Juul, Horswell, Stuart, Grönroos, Eva, Favero, Francesco, Rowan, Andrew J., Matthews, Nicholas, Begum, Sharmin, Phillimore, Benjamin, Burrell, Rebecca, Oukrif, Dahmane, Spencer-Dene, Bradley, Kovac, Michal, Stamp, Gordon, Stewart, Aengus, Danielsen, Havard, Novelli, Marco, Tomlinson, Ian, Swanton, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225404/
https://www.ncbi.nlm.nih.gov/pubmed/28073006
http://dx.doi.org/10.1016/j.ccell.2016.11.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225404/
https://www.ncbi.nlm.nih.gov/pubmed/28073006
http://dx.doi.org/10.1016/j.ccell.2016.11.001

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