Cargando…
Understanding the molecular mechanism for the differential inhibitory activities of compounds against MTH1
MTH1 can hydrolyze oxidized nucleotides and is required for cancer survival. The IC(50) values were 0.8 nM for TH287 with a methyl substitution, 5.0 nM for TH588 with a cyclopropyl substitution, and 2.1 μM for TH650 with an oxetanyl substitution. Thus, it is very significant to understand inhibitory...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225434/ https://www.ncbi.nlm.nih.gov/pubmed/28074893 http://dx.doi.org/10.1038/srep40557 |