Cargando…

A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins

Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation. Consequently, mutations in specific integrins, or their deregulated expression, are associated with a variet...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kapp, Tobias G., Rechenmacher, Florian, Neubauer, Stefanie, Maltsev, Oleg V., Cavalcanti-Adam, Elisabetta A., Zarka, Revital, Reuning, Ute, Notni, Johannes, Wester, Hans-Jürgen, Mas-Moruno, Carlos, Spatz, Joachim, Geiger, Benjamin, Kessler, Horst
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225454/ https://www.ncbi.nlm.nih.gov/pubmed/28074920 http://dx.doi.org/10.1038/srep39805

Ejemplares similares

Exploring the Role of RGD-Recognizing Integrins in Cancer
por: Nieberler, Markus, et al.
Publicado: (2017)

RGD-Binding Integrins Revisited: How Recently Discovered Functions and Novel Synthetic Ligands (Re-)Shape an Ever-Evolving Field
por: Ludwig, Beatrice S., et al.
Publicado: (2021)

Tumor Targeting via Integrin Ligands
por: Marelli, Udaya Kiran, et al.
Publicado: (2013)

Interface Immobilization Chemistry of cRGD-based Peptides Regulates Integrin Mediated Cell Adhesion
por: Pallarola, Diego, et al.
Publicado: (2014)

Comparison of cyclic RGD peptides for α(v)β(3) integrin detection in a rat model of myocardial infarction
por: Laitinen, Iina, et al.
Publicado: (2013)

Differential Modulation of Platelet Adhesion and Spreading by Adhesive Ligand Density
por: Zarka, Revital, et al.
Publicado: (2019)

Hydrogel Micropillars with Integrin Selective Peptidomimetic Functionalized Nanopatterned Tops: A New Tool for the Measurement of Cell Traction Forces Transmitted through α(v)β(3)- or α(5)β(1)-Integrins
por: Rahmouni, Sabri, et al.
Publicado: (2013)

Selective binding and lateral clustering of α5β1 and αvβ3 integrins: Unraveling the spatial requirements for cell spreading and focal adhesion assembly
por: Schaufler, Viktoria, et al.
Publicado: (2016)

Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation
por: Mas-Moruno, Carlos, et al.
Publicado: (2010)

Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands
por: Fraioli, Roberta, et al.
Publicado: (2017)

Therapeutic Radiopharmaceuticals Targeting Integrin αvβ6
por: Färber, Stefanie Felicitas, et al.
Publicado: (2018)

Substrate engagement of integrins α(5)β(1) and α(v)β(3) is necessary, but not sufficient, for high directional persistence in migration on fibronectin
por: Missirlis, Dimitris, et al.
Publicado: (2016)

Minimal Synthetic Cells to Study Integrin-Mediated Adhesion
por: Frohnmayer, Johannes P, et al.
Publicado: (2015)

A Dual Molecular Biointerface Combining RGD and KRSR Sequences Improves Osteoblastic Functions by Synergizing Integrin and Cell-Membrane Proteoglycan Binding
por: Hoyos-Nogués, Mireia, et al.
Publicado: (2019)

Click Chemistry for the Synthesis of RGD-Containing Integrin Ligands
por: Colombo, Matteo, et al.
Publicado: (2010)

Molecular View on the iRGD Peptide Binding Mechanism: Implications for Integrin Activity and Selectivity Profiles
por: D’Amore, Vincenzo Maria, et al.
Publicado: (2023)

Noninvasive Visualization of the Activated αvβ3 Integrin in Cancer Patients by Positron Emission Tomography and [(18)F]Galacto-RGD
por: Haubner, Roland, et al.
Publicado: (2005)

Beyond RGD: virus interactions with integrins
por: Hussein, Hosni A. M., et al.
Publicado: (2015)

Distinct Effects of RGD-glycoproteins on Integrin-Mediated Adhesion and Osteogenic Differentiation of Human Mesenchymal Stem Cells
por: Schwab, Elisabeth H., et al.
Publicado: (2013)

Integrin Subtypes and Nanoscale Ligand Presentation Influence Drug Sensitivity in Cancer Cells
por: Young, Jennifer L., et al.
Publicado: (2020)

RGD Forever!—Past, Present, and Future of a 3-Letter-Code in Radiopharmacy and Life Sciences
por: Notni, Johannes
Publicado: (2022)

RGD-Binding Integrins in Head and Neck Cancers
por: Ahmedah, Hanadi Talal, et al.
Publicado: (2017)

Hierarchical Quatsome-RGD Nanoarchitectonic Surfaces for Enhanced Integrin-Mediated Cell Adhesion
por: Martínez-Miguel, Marc, et al.
Publicado: (2022)

PET Imaging of Integrin αVβ3 Expression
por: Beer, Ambros J., et al.
Publicado: (2011)

Tuning RGD Motif and Hyaluronan Density to Study Integrin Binding
por: Zapp, Cornelia, et al.
Publicado: (2018)

Integrin‐Targeting Fluorescent Proteins: Exploration of RGD Insertion Sites
por: Sonntag, Michael H., et al.
Publicado: (2017)

Synchronized cell attachment triggered by photo-activatable adhesive ligands allows QCM-based detection of early integrin binding
por: Iturri, Jagoba, et al.
Publicado: (2015)

Tracking a TGF-β activator in vivo: sensitive PET imaging of αvβ8-integrin with the Ga-68-labeled cyclic RGD octapeptide trimer Ga-68-Triveoctin
por: Quigley, Neil Gerard, et al.
Publicado: (2020)

Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation
por: Wei, Qiang, et al.
Publicado: (2015)

Helicobacter pylori Type IV Secretion Apparatus Exploits β1 Integrin in a Novel RGD-Independent Manner
por: Jiménez-Soto, Luisa F., et al.
Publicado: (2009)

Copresentation of BMP-6 and RGD Ligands Enhances Cell Adhesion and BMP-Mediated Signaling
por: Posa, Francesca, et al.
Publicado: (2019)

Perspective of α(v)β(6)-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions
por: Steiger, Katja, et al.
Publicado: (2017)

LIC12254 Is a Leptospiral Protein That Interacts with Integrins via the RGD Motif
por: Cavenague, Maria F., et al.
Publicado: (2023)

Short-fibre modification facilitates adenovirus-mediated gene delivery in rheumatoid arthritis synoviocytes and synovium: role of RGD and non-RGD binding integrins
por: Toh, M-L, et al.
Publicado: (2005)

In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography
por: Notni, Johannes, et al.
Publicado: (2019)

Correction to: In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography
por: Notni, Johannes, et al.
Publicado: (2019)

Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity
por: Di Russo, Jacopo, et al.
Publicado: (2021)

Pseudomonas aeruginosa PilY1 Binds Integrin in an RGD- and Calcium-Dependent Manner
por: Johnson, Michael D. L., et al.
Publicado: (2011)

The effect of antagonizing RGD-binding integrin activity in papillary thyroid cancer cell lines
por: Cheng, Weiwei, et al.
Publicado: (2016)

A new perspective in sepsis treatment: could RGD-dependent integrins be novel targets?
por: Nader, Danielle, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1hituvq86qfk4rvd1c683hcp7c