Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease

The small heat shock protein HSPB1 (Hsp27) is an ubiquitously expressed molecular chaperone able to regulate various cellular functions like actin dynamics, oxidative stress regulation and anti-apoptosis. So far disease causing mutations in HSPB1 have been associated with neurodegenerative diseases...

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Detalles Bibliográficos
Autores principales: Geuens, Thomas, De Winter, Vicky, Rajan, Nicholas, Achsel, Tilmann, Mateiu, Ligia, Almeida-Souza, Leonardo, Asselbergh, Bob, Bouhy, Delphine, Auer-Grumbach, Michaela, Bagni, Claudia, Timmerman, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225548/
https://www.ncbi.nlm.nih.gov/pubmed/28077174
http://dx.doi.org/10.1186/s40478-016-0407-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225548/
https://www.ncbi.nlm.nih.gov/pubmed/28077174
http://dx.doi.org/10.1186/s40478-016-0407-3

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