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Cannabinoid receptor 2 augments eosinophil responsiveness and aggravates allergen‐induced pulmonary inflammation in mice

BACKGROUND: Accumulation of activated eosinophils in tissue is a hallmark of allergic inflammation. The endocannabinoid 2‐arachidonoylglycerol (2‐AG) has been proposed to elicit eosinophil migration in a CB (2) receptor/G(i/o)‐dependent manner. However, it has been claimed recently that this process...

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Detalles Bibliográficos
Autores principales: Frei, R. B., Luschnig, P., Parzmair, G. P., Peinhaupt, M., Schranz, S., Fauland, A., Wheelock, C. E., Heinemann, A., Sturm, E. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225803/
https://www.ncbi.nlm.nih.gov/pubmed/26850094
http://dx.doi.org/10.1111/all.12858