Application of a systems pharmacology model for translational prediction of hERG‐mediated QTc prolongation

Drug‐induced QTc interval prolongation (Δ QTc) is a main surrogate for proarrhythmic risk assessment. A higher in vivo than in vitro potency for hERG‐mediated QTc prolongation has been suggested. Also, in vivo between‐species and patient populations’ sensitivity to drug‐induced QTc prolongation seem...

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Detalles Bibliográficos
Autores principales: Gotta, Verena, Yu, Zhiyi, Cools, Frank, van Ammel, Karel, Gallacher, David J., Visser, Sandra A. G., Sannajust, Frederick, Morissette, Pierre, Danhof, Meindert, van der Graaf, Piet H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226282/
https://www.ncbi.nlm.nih.gov/pubmed/28097003
http://dx.doi.org/10.1002/prp2.270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226282/
https://www.ncbi.nlm.nih.gov/pubmed/28097003
http://dx.doi.org/10.1002/prp2.270

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