Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion

Among ALDH isoforms, ALDH1L1 in the folate pathway showed highly increased expression in non-small-cell lung cancer cells (NSCLC). Based on the basic mechanism of ALDH converting aldehyde to carboxylic acid with by-product NADH, we suggested that ALDH1L1 may contribute to ATP production using NADH t...

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Detalles Bibliográficos
Autores principales: Kang, Joon Hee, Lee, Seon-Hyeong, Lee, Jae-Seon, Nam, Boas, Seong, Tae Wha, Son, Jaekyoung, Jang, Hyonchol, Hong, Kyeong Man, Lee, Cheolju, Kim, Soo-Youl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226516/
https://www.ncbi.nlm.nih.gov/pubmed/27384481
http://dx.doi.org/10.18632/oncotarget.10354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226516/
https://www.ncbi.nlm.nih.gov/pubmed/27384481
http://dx.doi.org/10.18632/oncotarget.10354

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