Targeting FGFR1 to suppress leukemogenesis in syndromic and de novo AML in murine models

Although over expression of chimeric FGFR1 kinase consistently leads to the development of AML in the rare Stem Cell Leukemia and Lymphoma syndrome, we now show that overexpression of FGFR1 is also seen in up to 20% of non-syndromic, de novo AML. To determine whether targeting FGFR1 in both of these...

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Detalles Bibliográficos
Autores principales: Wu, Qing, Bhole, Aaron, Qin, Haiyan, Karp, Judith, Malek, Sami, Cowell, John K, Ren, Mingqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226543/
https://www.ncbi.nlm.nih.gov/pubmed/27391347
http://dx.doi.org/10.18632/oncotarget.10438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226543/
https://www.ncbi.nlm.nih.gov/pubmed/27391347
http://dx.doi.org/10.18632/oncotarget.10438

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