Targeting synthetic lethality between the SRC kinase and the EPHB6 receptor may benefit cancer treatment

Application of tumor genome sequencing has identified numerous loss-of-function alterations in cancer cells. While these alterations are difficult to target using direct interventions, they may be attacked with the help of the synthetic lethality (SL) approach. In this approach, inhibition of one ge...

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Detalles Bibliográficos
Autores principales: Paul, James M., Toosi, Behzad, Vizeacoumar, Frederick S., Bhanumathy, Kalpana Kalyanasundaram, Li, Yue, Gerger, Courtney, Zawily, Amr El, Freywald, Tanya, Anderson, Deborah H., Mousseau, Darrell, Kanthan, Rani, Zhang, Zhaolei, Vizeacoumar, Franco J., Freywald, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226566/
https://www.ncbi.nlm.nih.gov/pubmed/27418135
http://dx.doi.org/10.18632/oncotarget.10569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226566/
https://www.ncbi.nlm.nih.gov/pubmed/27418135
http://dx.doi.org/10.18632/oncotarget.10569

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