SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells

Acquisition of BCR-ABL mutations underlies drug resistance of chronic myeloid leukemia (CML) to tyrosine kinase inhibitors, but the molecular mechanisms of mutation acquisition are poorly understood. We previously showed that lysine deacetylase sirtuin 1, SIRT1, promotes acquisition of BCR-ABL mutat...

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Detalles Bibliográficos
Autores principales: Roth, Mendel, Wang, Zhiqiang, Chen, Wen Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226577/
https://www.ncbi.nlm.nih.gov/pubmed/27384990
http://dx.doi.org/10.18632/oncotarget.10328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226577/
https://www.ncbi.nlm.nih.gov/pubmed/27384990
http://dx.doi.org/10.18632/oncotarget.10328

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