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SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells
Acquisition of BCR-ABL mutations underlies drug resistance of chronic myeloid leukemia (CML) to tyrosine kinase inhibitors, but the molecular mechanisms of mutation acquisition are poorly understood. We previously showed that lysine deacetylase sirtuin 1, SIRT1, promotes acquisition of BCR-ABL mutat...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226577/ https://www.ncbi.nlm.nih.gov/pubmed/27384990 http://dx.doi.org/10.18632/oncotarget.10328 |