Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer

BACKGROUND: The Aurora kinases are a family of serine/threonine kinases comprised of Aurora A, B, and C which execute critical steps in mitotic and meiotic progression. Alisertib (MLN8237) is an investigational Aurora A selective inhibitor that has demonstrated activity against a wide variety of tum...

Descripción completa

Detalles Bibliográficos
Autores principales: Pitts, Todd M., Bradshaw, Erica L., Bagby, Stacey M., Hyatt, Stephanie L., Selby, Heather M., Spreafico, Anna, Tentler, John J., McPhillips, Kelly, Klauck, Peter J., Capasso, Anna, Diamond, Jennifer R., Davis, S. Lindsey, Tan, Aik Choon, Arcaroli, John J., Purkey, Alicia, Messersmith, Wells A., Ecsedy, Jeffery A., Eckhardt, S. Gail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226583/
https://www.ncbi.nlm.nih.gov/pubmed/27385211
http://dx.doi.org/10.18632/oncotarget.10366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226583/
https://www.ncbi.nlm.nih.gov/pubmed/27385211
http://dx.doi.org/10.18632/oncotarget.10366

Ejemplares similares