Inhibition of canonical WNT/β-catenin signaling is involved in leflunomide (LEF)-mediated cytotoxic effects on renal carcinoma cells

Leflunomide (LEF), an inhibitor of dihydroorotate dehydrogenase (DHODH) in pyrimidine biosynthetic pathway, is an immunomodulatory agent approved for the treatment of rheumatoid arthritis. In this study, we show that LEF significantly reduced cell proliferation of renal carcinoma cells in a concentr...

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Detalles Bibliográficos
Autores principales: Chen, Yicheng, Huang, Qiaoli, Zhou, Hua, Wang, Yueping, Hu, Xian, Li, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226591/
https://www.ncbi.nlm.nih.gov/pubmed/27391060
http://dx.doi.org/10.18632/oncotarget.10409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226591/
https://www.ncbi.nlm.nih.gov/pubmed/27391060
http://dx.doi.org/10.18632/oncotarget.10409

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