BMP restricts stemness of intestinal Lgr5(+) stem cells by directly suppressing their signature genes

The intestinal epithelium possesses a remarkable self-renewal ability, which is mediated by actively proliferating Lgr5(+) stem cells. Bone morphogenetic protein (BMP) signalling represents one major counterforce that limits the hyperproliferation of intestinal epithelium, but the exact mechanism re...

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Detalles Bibliográficos
Autores principales: Qi, Zhen, Li, Yehua, Zhao, Bing, Xu, Chi, Liu, Yuan, Li, Haonan, Zhang, Bingjie, Wang, Xinquan, Yang, Xiao, Xie, Wei, Li, Baojie, Han, Jing-Dong Jackie, Chen, Ye-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227110/
https://www.ncbi.nlm.nih.gov/pubmed/28059064
http://dx.doi.org/10.1038/ncomms13824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227110/
https://www.ncbi.nlm.nih.gov/pubmed/28059064
http://dx.doi.org/10.1038/ncomms13824

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