Discovery and Mechanistic Characterization of Selective Inhibitors of H(2)S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide

Very recent studies indicate that sulfur atoms with oxidation state 0 or −1, called sulfane sulfurs, are the actual mediators of some physiological processes previously considered to be regulated by hydrogen sulfide (H(2)S). 3-Mercaptopyruvate sulfurtransferase (3MST), one of three H(2)S-producing e...

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Detalles Bibliográficos
Autores principales: Hanaoka, Kenjiro, Sasakura, Kiyoshi, Suwanai, Yusuke, Toma-Fukai, Sachiko, Shimamoto, Kazuhito, Takano, Yoko, Shibuya, Norihiro, Terai, Takuya, Komatsu, Toru, Ueno, Tasuku, Ogasawara, Yuki, Tsuchiya, Yukihiro, Watanabe, Yasuo, Kimura, Hideo, Wang, Chao, Uchiyama, Masanobu, Kojima, Hirotatsu, Okabe, Takayoshi, Urano, Yasuteru, Shimizu, Toshiyuki, Nagano, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228037/
https://www.ncbi.nlm.nih.gov/pubmed/28079151
http://dx.doi.org/10.1038/srep40227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228037/
https://www.ncbi.nlm.nih.gov/pubmed/28079151
http://dx.doi.org/10.1038/srep40227

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