Oxidized nucleotide insertion by pol β confounds ligation during base excision repair

Oxidative stress in cells can lead to accumulation of reactive oxygen species and oxidation of DNA precursors. Oxidized purine nucleotides can be inserted into DNA during replication and repair. The main pathway for correcting oxidized bases in DNA is base excision repair (BER), and in vertebrates D...

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Detalles Bibliográficos
Autores principales: Çağlayan, Melike, Horton, Julie K., Dai, Da-Peng, Stefanick, Donna F., Wilson, Samuel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228075/
https://www.ncbi.nlm.nih.gov/pubmed/28067232
http://dx.doi.org/10.1038/ncomms14045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228075/
https://www.ncbi.nlm.nih.gov/pubmed/28067232
http://dx.doi.org/10.1038/ncomms14045

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