Emerging links between m(6)A and misregulated mRNA methylation in cancer

N (6)-methyladenosine (m(6)A) in mRNA has emerged as a crucial epitranscriptomic modification that controls cellular differentiation and pluripotency. Recent studies are pointing to a role for the RNA methylation program in cancer self-renewal and cell fate, making this a new and promising therapeut...

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Detalles Bibliográficos
Autores principales: Jaffrey, Samie R., Kharas, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228104/
https://www.ncbi.nlm.nih.gov/pubmed/28081722
http://dx.doi.org/10.1186/s13073-016-0395-8
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author Jaffrey, Samie R.
Kharas, Michael G.
author_facet Jaffrey, Samie R.
Kharas, Michael G.
author_sort Jaffrey, Samie R.
collection PubMed
description N (6)-methyladenosine (m(6)A) in mRNA has emerged as a crucial epitranscriptomic modification that controls cellular differentiation and pluripotency. Recent studies are pointing to a role for the RNA methylation program in cancer self-renewal and cell fate, making this a new and promising therapeutic avenue for investigation.
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spelling pubmed-52281042017-01-17 Emerging links between m(6)A and misregulated mRNA methylation in cancer Jaffrey, Samie R. Kharas, Michael G. Genome Med Comment N (6)-methyladenosine (m(6)A) in mRNA has emerged as a crucial epitranscriptomic modification that controls cellular differentiation and pluripotency. Recent studies are pointing to a role for the RNA methylation program in cancer self-renewal and cell fate, making this a new and promising therapeutic avenue for investigation. BioMed Central 2017-01-12 /pmc/articles/PMC5228104/ /pubmed/28081722 http://dx.doi.org/10.1186/s13073-016-0395-8 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Jaffrey, Samie R.
Kharas, Michael G.
Emerging links between m(6)A and misregulated mRNA methylation in cancer
title Emerging links between m(6)A and misregulated mRNA methylation in cancer
title_full Emerging links between m(6)A and misregulated mRNA methylation in cancer
title_fullStr Emerging links between m(6)A and misregulated mRNA methylation in cancer
title_full_unstemmed Emerging links between m(6)A and misregulated mRNA methylation in cancer
title_short Emerging links between m(6)A and misregulated mRNA methylation in cancer
title_sort emerging links between m(6)a and misregulated mrna methylation in cancer
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228104/
https://www.ncbi.nlm.nih.gov/pubmed/28081722
http://dx.doi.org/10.1186/s13073-016-0395-8
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