X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design

Ubiquitin-like domain 2 (Ubl2) is immediately adjacent to the N-terminus of the papain-like protease (PLpro) domain in coronavirus polyproteins, and it may play a critical role in protease regulation and stability as well as in viral infection. However, our recent cellular studies reveal that removi...

Descripción completa

Detalles Bibliográficos
Autores principales: Clasman, Jozlyn R., Báez-Santos, Yahira M., Mettelman, Robert C., O’Brien, Amornrat, Baker, Susan C., Mesecar, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228125/
https://www.ncbi.nlm.nih.gov/pubmed/28079137
http://dx.doi.org/10.1038/srep40292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228125/
https://www.ncbi.nlm.nih.gov/pubmed/28079137
http://dx.doi.org/10.1038/srep40292

Ejemplares similares