Cargando…

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms

People with Type 2 diabetes mellitus (T2DM) have reduced bone mineral density and an increased risk of fractures due to altered mesenchymal stem cell (MSC) differentiation in the bone marrow. This leads to a shift in the balance of differentiation away from bone formation (osteogenesis) in favour of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Suet Ching, Brooks, Rebecca, Houskeeper, Jessica, Bremner, Shaun K., Dunlop, Julia, Viollet, Benoit, Logan, Pamela J., Salt, Ian P., Ahmed, S. Faisal, Yarwood, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	North Holland Publishing 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228588/ https://www.ncbi.nlm.nih.gov/pubmed/27856330 http://dx.doi.org/10.1016/j.mce.2016.11.011

Ejemplares similares

Corrigendum to “Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms” [Mol. Cell. Endocrinol. 440 15 January 2017 57–68]
por: Chen, S.C., et al.
Publicado: (2017)

AMP-independent activator of AMPK for treatment of mitochondrial disorders
por: Moore, Tereza, et al.
Publicado: (2020)

AMPK is not required for the effect of metformin on the inhibition of BMP6-induced hepcidin gene expression in hepatocytes
por: Deschemin, Jean-Christophe, et al.
Publicado: (2017)

Defining the Contribution of AMP-activated Protein Kinase (AMPK) and Protein Kinase C (PKC) in Regulation of Glucose Uptake by Metformin in Skeletal Muscle Cells
por: Turban, Sophie, et al.
Publicado: (2012)

Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy
por: Yamada, Eijiro, et al.
Publicado: (2016)

AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2
por: Philippe, Chloé, et al.
Publicado: (2018)

Activation of AMPK for a Break in Hepatic Lipid Accumulation and Circulating Cholesterol
por: Foretz, Marc, et al.
Publicado: (2018)

Inhibition of Adipogenesis by Diphlorethohydroxycarmalol (DPHC) through AMPK Activation in Adipocytes
por: Kang, Min-Cheol, et al.
Publicado: (2019)

Modulation of cardiac cAMP signaling by AMPK and its adjustments in pressure overload-induced myocardial dysfunction in rat and mouse
por: Garnier, Anne, et al.
Publicado: (2023)

Emerging Role of cAMP/AMPK Signaling
por: Aslam, Muhammad, et al.
Publicado: (2022)

Adiponectin Facilitates Postconditioning Cardioprotection through Both AMPK-Dependent Nuclear and AMPK-Independent Mitochondrial STAT3 Activation
por: Zhu, Qiqi, et al.
Publicado: (2020)

Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons
por: Bayliss, Jacqueline A., et al.
Publicado: (2016)

Dibenzoylmethane Exerts Metabolic Activity through Regulation of AMP-Activated Protein Kinase (AMPK)-Mediated Glucose Uptake and Adipogenesis Pathways
por: Kim, Nami, et al.
Publicado: (2015)

Specific Deletion of AMP-Activated Protein Kinase (α1AMPK) in Murine Oocytes Alters Junctional Protein Expression and Mitochondrial Physiology
por: Bertoldo, Michael J., et al.
Publicado: (2015)

Metabolic regulation by the intestinal metformin-AMPK axis
por: Zhang, Song-Yang, et al.
Publicado: (2022)

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation
por: Vara-Ciruelos, Diana, et al.
Publicado: (2019)

AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation In Vivo
por: Foretz, Marc, et al.
Publicado: (2018)

Editorial: AMPK and mTOR Beyond Signaling: Emerging Roles in Transcriptional Regulation
por: Audet-Walsh, Étienne, et al.
Publicado: (2021)

The AMP-Dependent Protein Kinase (AMPK) Activator A-769662 Causes Arterial Relaxation by Reducing Cytosolic Free Calcium Independently of an Increase in AMPK Phosphorylation
por: Huang, Yi, et al.
Publicado: (2017)

AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications
por: Kumagai, Asako, et al.
Publicado: (2018)

Differential effects of AMPK agonists on cell growth and metabolism
por: Vincent, Emma E., et al.
Publicado: (2014)

Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK
por: Fu, Xing, et al.
Publicado: (2016)

AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer
por: Choudhury, Yashmin, et al.
Publicado: (2014)

AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis
por: Guma, Monica, et al.
Publicado: (2015)

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR
por: Collodet, Caterina, et al.
Publicado: (2019)

AMPK in skeletal muscle function and metabolism
por: Kjøbsted, Rasmus, et al.
Publicado: (2018)

The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective
por: Agius, Loranne, et al.
Publicado: (2020)

Demystifying the Relationship Between Metformin, AMPK, and Doxorubicin Cardiotoxicity
por: Singh, Manrose, et al.
Publicado: (2022)

Hyperosmotic Stress Initiates AMPK-Independent Autophagy and AMPK- and Autophagy-Independent Depletion of Thioredoxin 1 and Glyoxalase 2 in HT22 Nerve Cells
por: Dafre, Alcir Luiz, et al.
Publicado: (2019)

Role of AMPK in UVB-induced DNA damage repair and growth control
por: Wu, Chunli, et al.
Publicado: (2012)

Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival
por: Zhao, Baozhong, et al.
Publicado: (2016)

AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain
por: Ramamurthy, Santosh, et al.
Publicado: (2012)

Roles of AMP-Activated Protein Kinase (AMPK) in Mammalian Reproduction
por: Yang, Weina, et al.
Publicado: (2020)

Regulation of the Proteasome by AMPK in Endothelial Cells: The Role of O-GlcNAc Transferase (OGT)
por: Xu, Jian, et al.
Publicado: (2012)

AMPK Suppresses Vascular Inflammation In Vivo by Inhibiting Signal Transducer and Activator of Transcription-1
por: He, Chaoyong, et al.
Publicado: (2015)

Flubendiamide Enhances Adipogenesis and Inhibits AMPKα in 3T3-L1 Adipocytes
por: Sun, Quancai, et al.
Publicado: (2018)

Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation
por: Groenendijk, Floris H, et al.
Publicado: (2015)

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK
por: Wang, Yu, et al.
Publicado: (2019)

Metformin regulates myoblast differentiation through an AMPK-dependent mechanism
por: Maniscalco, Eleonora, et al.
Publicado: (2023)

AMPK Activation Promotes Tight Junction Assembly in Intestinal Epithelial Caco-2 Cells
por: Olivier, Séverine, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_k9s161cdsdmufv773dc6ui3g2v