Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells

Tumor cell proliferation and migration processes are regulated by multiple metabolic pathways including glycolysis and de novo lipogenesis. Since acetyl-CoA carboxylase (ACC) is at the junction of lipids synthesis and oxidative metabolic pathways, we investigated whether use of a dual ACC inhibitor...

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Detalles Bibliográficos
Autores principales: Jones, Jessica E. C., Esler, William P., Patel, Rushi, Lanba, Adhiraj, Vera, Nicholas B., Pfefferkorn, Jeffrey A., Vernochet, Cecile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231342/
https://www.ncbi.nlm.nih.gov/pubmed/28081256
http://dx.doi.org/10.1371/journal.pone.0169566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231342/
https://www.ncbi.nlm.nih.gov/pubmed/28081256
http://dx.doi.org/10.1371/journal.pone.0169566

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