Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation

The endoplasmic reticulum (ER) mediates the folding, maturation, and deployment of the secretory proteome. Proteins that fail to achieve their native conformation are retained in the ER and targeted for clearance by ER-associated degradation (ERAD), a sophisticated process that mediates the ubiquiti...

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Detalles Bibliográficos
Autores principales: To, Milton, Peterson, Clark W. H., Roberts, Melissa A., Counihan, Jessica L., Wu, Tiffany T., Forster, Mercedes S., Nomura, Daniel K., Olzmann, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231896/
https://www.ncbi.nlm.nih.gov/pubmed/27881664
http://dx.doi.org/10.1091/mbc.E16-07-0483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231896/
https://www.ncbi.nlm.nih.gov/pubmed/27881664
http://dx.doi.org/10.1091/mbc.E16-07-0483

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